Is laparoscopic simultaneous resection for colorectal cancer and synchronous liver metastases safe and useful?
Editorial Commentary

Is laparoscopic simultaneous resection for colorectal cancer and synchronous liver metastases safe and useful?

Yasushi Hasegawa, Hiroyuki Nitta, Takeshi Takahara, Hirokatsu Katagiri, Akira Sasaki

Department of Surgery, Iwate Medical University School of Medicine, Morioka, Japan

Correspondence to: Yasushi Hasegawa, MD, PhD. Department of Surgery, Iwate Medical University School of Medicine, 19-1 Uchimaru, Morioka City, 020-8505 Iwate, Japan. Email: hasegawayas@yahoo.co.jp.

Comment on: Moris D, Tsilimigras DI, Machairas N, et al. Laparoscopic synchronous resection of colorectal cancer and liver metastases: A systematic review. J Surg Oncol 2019;119:30-9.


Received: 13 August 2019; Accepted: 23 August 2019; Published: 23 September 2019.

doi: 10.21037/ls.2019.08.06


We have read the article by Moris et al., titled “Laparoscopic synchronous resection of colorectal cancer and liver metastases: A systematic review” published in the Journal of Surgical Oncology (1). We had considerable interest in their analyses on the outcomes of laparoscopic simultaneous resection (LSR) for colorectal cancer (CRC) and colorectal cancer liver metastases (CRCLM). Their study concluded that LSR is a safe and feasible approach compared to open simultaneous resection (OSR), for selected patients with synchronous CRCLM. On the other hand, they also stated that the number of patients included in the study was very small, and therefore the conclusion was considerably restricted.

The advantages of simultaneous resection for CRC and CRCLM are a considerably shorter length of total hospital stay and cancer-free condition, after one operation, without the risk of progression of the remaining tumor. In fact, simultaneous resections of CRC and CRCLM have been shown to be favorable in several studies (2-5). However, simultaneous resection should be discouraged when major hepatectomy or complex rectal surgery is planned, because of a significantly higher incidence of postoperative mortality and morbidity (6,7). Furthermore, based on data taken from the NSQIP database, synchronous resection was associated with a higher incidence of major complications, and the tendency was toward higher mortality (8). On the other hand, Abelson et al. reported that simultaneous resection was comparable to staged resection, even when the patients underwent more complex operations (hepatic total lobectomy and low anterior resection, or abdominoperineal resection) (9). Recent progression of surgical skills and perioperative management might improve the postoperative outcomes of simultaneous resection for more complex procedures.

Laparoscopic procedure is being used increasingly for colorectal surgery and has become a gold standard in some countries. There are many reports comparing it to the open procedure, and the benefits of laparoscopic colorectal resection have been reported in various operative procedures and clinical settings. Regarding transverse colectomy, laparoscopy provides similar survival benefits, earlier postoperative recovery, and a shorter hospital stay (10). Laparoscopic rectal resection is associated with less blood loss and smaller incision length than open rectal resection, with no differences in postoperative morbidity and mortality (11). In the Cochrane Database Systematic Review, there is moderate quality evidence that laparoscopic total mesorectal excision results in better short-term postoperative outcomes in terms of recovery for non-locally advanced rectal cancer. The length of hospital stay was reduced, and the time to the first defecation was shorter. The estimated effects of laparoscopic and open total mesorectal excision on local recurrence and overall survival were similar (12). Laparoscopic abdominoperineal resection can reduce postoperative complications, and lead to faster postoperative recovery. In addition, laparoscopic abdominoperineal resection is not inferior to open abdominoperineal resection in terms of oncological clearance, recurrence rate, and long-term survival (13). Furthermore, laparoscopic colorectal resection, including complex procedures is safe and feasible compared to open resection in terms of both short-term and long-term outcomes.

The use of laparoscopic liver resection (LLR) for CRCLM has a relatively short history and is still limited. The learning curve and operative devisal have been discussed, especially in major hepatectomy (14-17). Additionally, the operative time is often longer for LLR than for open liver resection (18,19). Of course, the advantages of LLR have been well known and include fewer complications, transfusions, and analgesic requirements; less blood loss and pain; shorter hospital stays; and improved cosmetic results (20-23). Comparable results were reported regarding the long-term outcomes of LLR for CRCLM (22,23). Thus, LLR is now developing and evolving, and may increasingly improve operative outcomes.

The laparoscopic approach reduces surgical wound trauma, leading to lesser postoperative pain and earlier postoperative rehabilitation; therefore, LSR could have advantages compared to OSR in terms of short-term outcomes, e.g., less pain and analgesic requirement, shorter hospital stays, and improved cosmetic results. Moreover, LLR decreases intraoperative blood loss owing to pneumoperitoneum and magnification of the surgical view. Therefore, LSR can overcome the concerns associated with major hepatectomy and complex colorectal resection. However, there are only a few studies on LSR; thus, further larger-scale studies are required in order to confirm these findings.


Acknowledgments

None.


Footnote

Conflicts of Interest: The authors have no conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.


References

  1. Moris D, Tsilimigras DI, Machairas N, et al. Laparoscopic synchronous resection of colorectal cancer and liver metastases: A systematic review. J Surg Oncol 2019;119:30-9. [Crossref] [PubMed]
  2. Adam R, de Gramont A, Figueras J, et al. Managing synchronous liver metastases from colorectal cancer: a multidisciplinary international consensus. Cancer Treat Rev 2015;41:729-41. [Crossref] [PubMed]
  3. Yin Z, Liu C, Chen Y, et al. Timing of hepatectomy in resectable synchronous colorectal liver metastases (SCRLM): Simultaneous or delayed?. Hepatology 2013;57:2346-57. [Crossref] [PubMed]
  4. Feng Q, Wei Y, Zhu D, et al. Timing of hepatectomy for resectable synchronous colorectal liver metastases: for whom simultaneous resection is more suitable--a meta-analysis. PLoS One 2014;9:e104348. [Crossref] [PubMed]
  5. Gavriilidis P, Sutcliffe RP, Hodson J, et al. Simultaneous versus delayed hepatectomy for synchronous colorectal liver metastases: a systematic review and meta-analysis. HPB (Oxford) 2018;20:11-9. [Crossref] [PubMed]
  6. Reddy SK, Pawlik TM, Zorzi D, et al. Simultaneous resections of colorectal cancer and synchronous liver metastases: a multi-institutional analysis. Ann Surg Oncol 2007;14:3481-91. [Crossref] [PubMed]
  7. Ono Y, Saiura A, Arita J, et al. Short-Term Outcomes after Simultaneous Colorectal and Major Hepatic Resection for Synchronous Colorectal Liver Metastases. Dig Surg 2017;34:447-54. [Crossref] [PubMed]
  8. Jones TJ, Murphy AE, Tameron A, et al. Trends and Outcomes of Synchronous Resection of Colorectal Metastasis in the Modern Era-Analysis of Targeted Hepatic NSQIP Database. J Surg Res 2019;238:35-40. [Crossref] [PubMed]
  9. Abelson JS, Michelassi F, Sun T, et al. Simultaneous Resection for Synchronous Colorectal Liver Metastasis: the New Standard of Care? J Gastrointest Surg 2017;21:975-82. [Crossref] [PubMed]
  10. Gavriilidis P, Katsanos K. Laparoscopic Versus Open Transverse Colectomy: A Systematic Review and Meta-Analysis. World J Surg 2018;42:3008-14. [Crossref] [PubMed]
  11. Martínez-Pérez A, Carra MC, Brunetti F, et al. Short-term clinical outcomes of laparoscopic vs open rectal excision for rectal cancer: A systematic review and meta-analysis. World J Gastroenterol 2017;23:7906-16. [Crossref] [PubMed]
  12. Vennix S, Pelzers L, Bouvy N, et al. Laparoscopic versus open total mesorectal excision for rectal cancer. Cochrane Database Syst Rev 2014.CD005200. [PubMed]
  13. Zhang X, Wu Q, Hu T, et al. Laparoscopic Versus Conventional Open Abdominoperineal Resection for Rectal Cancer: An Updated Systematic Review and Meta-Analysis. J Laparoendosc Adv Surg Tech A 2018;28:526-39. [Crossref] [PubMed]
  14. Kaneko H, Otsuka Y, Kubota Y, et al. Evolution and revolution of laparoscopic liver resection in Japan. Ann Gastroenterol Surg 2017;1:33-43. [Crossref] [PubMed]
  15. Hasegawa Y, Nitta H, Takahara T, et al. Laparoscopic left hemihepatectomy is suitable as a first step in pure laparoscopic major hepatectomy. Ann Gastroenterol Surg 2018;2:376-82. [Crossref] [PubMed]
  16. van der Poel MJ, Besselink MG, Cipriani F, et al. Outcome and Learning Curve in 159 Consecutive Patients Undergoing Total Laparoscopic Hemihepatectomy. JAMA Surg 2016;151:923-8. [Crossref] [PubMed]
  17. Hasegawa Y, Wakabayashi G, Nitta H, et al. A novel model for prediction of pure laparoscopic liver resection surgical difficulty. Surg Endosc 2017;31:5356-63. [Crossref] [PubMed]
  18. Kasai M, Cipriani F, Gayet B, et al. Laparoscopic versus open major hepatectomy: a systematic review and meta-analysis of individual patient data. Surgery 2018;163:985-95. [Crossref] [PubMed]
  19. Hasegawa Y, Nitta H, Sasaki A, et al. Long-term outcomes of laparoscopic versus open liver resection for liver metastases from colorectal cancer: A comparative analysis of 168 consecutive cases at a single center. Surgery 2015;157:1065-72. [Crossref] [PubMed]
  20. Ciria R, Cherqui D, Geller DA, et al. Comparative Short-term Benefits of Laparoscopic Liver Resection: 9000 Cases and Climbing. Ann Surg 2016;263:761-77. [Crossref] [PubMed]
  21. Cauchy F, Fuks D, Nomi T, et al. Benefits of Laparoscopy in Elderly Patients Requiring Major Liver Resection. J Am Coll Surg 2016;222:174-84.e10. [Crossref] [PubMed]
  22. Beppu T, Wakabayashi G, Hasegawa K, et al. Long-term and perioperative outcomes of laparoscopic versus open liver resection for colorectal liver metastases with propensity score matching: a multi-institutional Japanese study. J Hepatobiliary Pancreat Sci 2015;22:711-20. [Crossref] [PubMed]
  23. Ciria R, Ocaña S, Gomez-Luque I, et al. A systematic review and meta-analysis comparing the short- and long-term outcomes for laparoscopic and open liver resections for liver metastases from colorectal cancer. Surg Endosc 2019. [Epub ahead of print]. [Crossref] [PubMed]
doi: 10.21037/ls.2019.08.06
Cite this article as: Hasegawa Y, Nitta H, Takahara T, Katagiri H, Sasaki A. Is laparoscopic simultaneous resection for colorectal cancer and synchronous liver metastases safe and useful? Laparosc Surg 2019;3:42.