Robot-assisted pancreaticoduodenectomy with vascular resection: technical details and results from a high-volume center
Original Article

Robot-assisted pancreaticoduodenectomy with vascular resection: technical details and results from a high-volume center

Emanuele Federico Kauffmann1^, Niccolò Napoli1, Francesca Menonna1, Valerio Genovese1, Concetta Cacace1, Cacciato Insilla Andrea2, Campani Daniela2, Fabio Vistoli1, Gabriella Amorese3, Ugo Boggi1

1Division of General and Transplant Surgery, University of Pisa, Pisa, Italy; 2Division of Pathology, University of Pisa, Pisa, Italy; 3Division of Anesthesia and Intensive Care, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy

Contributions: (I) Conception and design: EF Kauffmann, U Boggi; (II) Administrative support: U Boggi, F Vistoli; (III) Provision of study materials or patients: EF Kauffmann, N Napoli, F Menonna, V Genovese, C Cacace, F Vistoli, U Boggi; (IV) Collection and assembly of data: EF Kauffmann, N Napoli, F Menonna, V Genovese, C Cacace, F Vistoli, G Amorese, U Boggi; (V) Data analysis and interpretation: EF Kauffmann, F Menonna, U Boggi; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.

^ORCID: 0000-0001-7634-4844.

Correspondence to: Emanuele Federico Kauffmann. Division of General and Transplant Surgery, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy. Email:

Background: Pancreaticoduodenectomy with vein resection (PD-VR) is widely accepted as a standard procedure to achieve a higher rate of R0 resections in borderline resectable pancreatic tumors. Thanks to the availability of newer technologies, such as the da Vinci Surgical System, several high-volume centers are reporting small series of minimally invasive PD-VR.

Methods: A retrospective review of a prospectively maintained database was performed to identify patients who underwent robot-assisted PD-VR (RAPD-VR) between May 2011 and December 2019. The following factors were specifically analyzed: intraoperative results, post-operative complications, mortality at 90 days, patency of vascular reconstructions, overall survival (OS) and disease-free survival (DFS).

Results: During the study period 184 patients underwent RAPD, including 22 who received a RAPD-VR (12.0%). The superior mesenteric vein was resected in 9 patients (40.9%), the portal vein in 3 patients (13.6%) and the spleno-mesenteric junction in 10 patients (45.5%). Based on the classification provided by the International Study Group on Pancreatic Surgery these procedures were classified as follows: 1 type I (4.5%), 3 type II (13.6%), 10 type III (45.5%) and 8 type IV (36.4%). In no patient the splenic vein was ligated and left behind. The splenic vein was always reimplanted either on the porto-mesenteric axis or in the inferior vena cava. All but one procedure, were completed under robotic assistance (conversion rate 1/22; 4.5%) after a mean operative time of 610.0±83.5 minutes. Median estimated blood loss was 899.7 mL (719.4–1,430.2 mL), with 2 patients (9.1%) receiving intraoperative blood transfusions. Sixteen patients developed post-operative complications (72.7%), graded ≥III (according to Clavien-Dindo) in 5 patients (22.7%). Two patients died within 90 days, accounting for a postoperative mortality of 9.1%. Interestingly, post-operative pancreatic fistula (grade B) occurred in only 1 patient (4.5%). Repeat surgery was required in 4 patients (18.2%) and hospital readmission in 1 patient (4.5%). At the longest available follow-up, vein reconstruction was patent in 19 patients (86.4%). Eighteen patients had a final diagnosis of pancreatic ductal adenocarcinoma (81.8%). After circumferential study of resection margins, microscopic tumor residual ≤1 mm was found in 11 patients (50.0%). The mean number of examined lymph nodes was 42.2 (±16.3), and vascular infiltration was confirmed in 13 patients (59.1%). Median OS was 39.7 (27.5–not available) and DFS 32.9 (11.5–45.8). Tumor recurrence was identified in 6 patients (27.3%). One patient (4.5%) developed isolated local recurrence.

Conclusions: We have shown the feasibility of RAPD-VR. The results reported herein need to be confirmed in larger series and their generalizability remains to be established.

Keywords: Pancreas; robot; robotic; vascular resection; pancreatoduodenectomy

Received: 25 May 2020; Accepted: 09 July 2020; Published: 15 October 2020.

doi: 10.21037/ls-20-94

Video 1 Robot-assisted pancreaticoduodenectomy with vein resection. The liver is retracted by placing sutures between the anterior margin of the right and left lobe and the diaphragmatic dome. The procedure begins by clearing the hepatoduodenal ligament as this maneuver permits clear identification of key vascular landmarks (i.e., hepatic artery and portal vein). The right gastric vessels are ligated and divided. Next, the lesser sac is opened, and the right gastroepiploic vessels are ligated and divided close to the pylorus. Division of the duodenum, approximately one centimeter distal to the pylorus, improves exposure of the region of the head of the pancreas. Now, the common hepatic artery is encircled with a vessel loop and the gastroduodenal artery double ligated and divided. In this patient, a replaced right hepatic artery originating from the superior mesenteric arty was also present. This vessel was also encircled with a vessel loop. Division of the gastroduodenal artery brings the portal vein comes in clear view. The superior mesenteric vein (SMV) is now identified at the inferior margin of the pancreatic neck and the pancreas is divided above the vein using the harmonic scalpel. The pancreatic duct is divided using scissors. Frozen section histology of the pancreatic margin is obtained. The duodenum is now hanged using the fourth robotic arm and a wide Kocher maneuver is performed and the first jejunal loop is mobilized to the right of the superior mesenteric vessels. The jejunal mesentery is then divided working from this perspective using a harmonic scalpel. The first jejunal loop is divided using a robotized endoscopic stapler loaded with a vascular cartridge. Transposition of the first jejunal loop to the right side of the mesenteric vessels facilitates the approach to the superior mesenteric artery (SMA). The SMV is encircled with vessel loop for an easier handling during retroperitoneal dissections. Colic and jejunal veins, crossing above the SMA are ligated and divided to facilitate arterial exposure. As dissection proceeds along the periadventitial plane of the SMA the replaced right hepatic artery is eventually identified and preserved. The bile duct is now divided to improve exposure and permit full dissection of the replaced right hepatic artery. Encirclement of the splenic vein facilitates further dissection along the SMA, including ligature and division of a pancreaticoduodenal artery. Dissection proceeds until the celiac trunk is reached. At this stage the SMA is further approached from the posterior approach to permit safer identification of the inferior pancreaticoduodenal artery, known to arise from the replaced right hepatic artery. The specimen is now completely mobilized en-bloc with the vein segment believed to be involved by the tumor. In preparation for a type II resection of the vein, a patch of the peritoneum covering the right kidney is harvested. Subsequently, the SMA, the SMV, the splenic vein and the portal vein are cross-clamped using laparoscopic bulldogs and a large venous patch is removed en-bloc with the tumor. The peritoneal patch is sutured to the venous defect using two half running sutures of 7/0 e-PTFE. Bulldog clamps are removed and hemostasis is perfected. In preparation for digestive reconstruction, the round ligament of the liver is fully mobilized and wrapped around the hepatic artery to protect this vessel against erosion, in case of post-operative pancreatic fistula. The pancreatic anastomosis is performed according to a modified Blumgart technique. The external layer employs transfix pancreatic sutures using 4/0 e-PTFE sutures. The duct-to-mucosa anastomosis is performed using interrupted sutures of 5/0 polydioxanone (PDS). The hepaticojejunostomy is performed next 15 centimeters downstream on the same jejunal loop. A double layer running suture technique is employed, using four half-running sutures of 5/0 PDS. Digestive reconstruction is performed 20–25 centimeters downstream using a double layer technique. The specimen is retrieved in an endoscopic bag through a small suprapubic transverse incision and two pigtail drains (14 Fr) are left in the surgical bed.
Video 2 Type 3 vein resection during robot-assisted pancreaticoduodenectomy. In a patient requiring a type 4 vein resection, because of tumor abutment to the port-mesenteric junction, the superior mesenteric artery (SMA) and the superior mesenteric vein (SMV) are cross-clamped using laparoscopic bulldog clamps. To maintain some portal flow to the liver through the splenic vein during the construction of the first vascular anastomosis the SMV is occlude proximally using a large hem-o-look clip. A deceased donor iliac vein is used as a jump graft and is anastomosed to the SMV using to half-running sutures of 6/0 e-PTFE. After cross-clamping of the splenic and the portal vein, the tumor is removed en-bloc with the involved vein segment and the jump graft is anastomosed distally to the spleno-portal junction.
Video 3 Type 4 vein resection during robot-assisted pancreaticoduodenectomy. This video shows a case requiring a type 3 vein resection. After vascular cross-clamping, the specimen is resected en-bloc with the attached vein segment. In preparation for direct vein repair a 6/0 e-PTFE suture is placed at one corner of the anastomosis and tied to approximate the two cut ends. The anastomosis is then performed using two half-running sutures of 6/0 e-PTFE. The posterior wall of the anastomosis is sutured form inside. The suture is tied with a growth factor and the vascular clamps are removed.


The aggressive biology of pancreatic cancer makes the distinction between curative and palliative treatments largely speculative. However, in the absence of detectable metastases in distant organs, radical resection of the primary tumor is considered the standard of care. Resection of a seemingly localized pancreatic cancer is indeed the only treatment aiming to cure. In patients who will not be eventually cured, resection prolongs survival and improves quality of life when compared to alternative palliative treatments (1,2).

Unfortunately, a truly localized disease permitting resection is observed in only 20% of the patients with pancreatic cancer. The remaining patients are either diagnosed with overtly metastatic disease (50%) or with borderline resectable/locally advanced tumors (30%) (1,3). Borderline resectable tumors (4) are a particular group of neoplasms in which resection is technically possible but at a higher risk of microscopic margin positivity (R1), mostly because of tumor abutment on the superior mesenteric-portal vein. In these patients, typically after neoadjuvant treatments, pancreatoduodenectomy with en-bloc resection of the involved vein segment (PD-VR) is devised to increase the probability of radical resection (R0) (1,5).

Not surprisingly, PD-VR is more complex than pancreatoduodenectomy alone (6-9). Therefore, this operation has been performed mostly through a conventional, open, approach (10,11) In recent years, few specialized centers, have reported small series of PD-VR performed through a minimally invasive approach (10,12-15).

Historically, our group has been proactive in pursuing PD-VR (16). Overall, we have performed over 500 pancreatectomies with associated vascular procedures, including over 150 truly extended procedures including also arterial resections. We have performed the first robot-assisted pancreatoduodenectomy (RAPD) in 2008 and, after some experience, we have started to consider for a robotic approach also patients with limited vascular involvement. We herein report our initial experience with RAPD with en-bloc resection of the superior mesenteric-portal vein [robot-assisted pancreaticoduodenectomy with vascular resection (RAPD-VR)] and we describe the technique that we have developed. We present the following article in accordance with the STROBE reporting checklist (available at


A prospectively maintained database was retrospectively revised to identify all patients who received a RAPD-VR between May 2011 and December 2019 at General Surgery and Transplant Unit (Azienda Ospedaliero Univeristaria Pisana; University of Pisa, Italy). The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013). The study was approved by ethics board of University of Pisa (CEAVNO) and informed consent was taken from all the patients.

Selection criteria

In general, as detailed previously (17,18), patients were carefully selected for RAPD. Concerning vascular involvement, at the beginning of our experience all types of vascular involvement was considered an absolute contraindication for a robotic approach. After some experience, limited vein involvement (i.e. unilateral contact, <180°, without distortion of vessel contour) was accepted when patients were considered otherwise suitable for RAPD (15). Overt arterial encasement was considered an absolute contraindication. Limited arterial involvement was considered on a case-by-case basis with great caution.

Outcome measures

The following parameters were recorded: operative time, estimated blood loss, rate of conversion, post-operative complications [classified according to the Dindo-Clavien (19)], incidence and severity of post-operative pancreatic fistula (POPF) (20), incidence and severity of delayed gastric emptying (21), and incidence and severity of post-pancreatectomy hemorrhage (22). Complications graded ≥ III were considered severe. The overall burden of postoperative complications was defined using the comprehensive complication index (23). Post-operative mortality was considered as any death occurring during the first 90 days or during the initial hospital stay if longer than 90 days. Overall survival (OS) and the disease-free survival (DFS) were calculated using the Kaplan-Meier method. The collection of the variables was prospective and through clinics during the first visit and the hospital staying. The follow-up was collected in the clinics or through interview.

Surgical technique

The surgical technique for RAPD-VR and RAPD was previously reported (24). Briefly, resectability was established after an artery first approach to both the superior mesenteric artery (SMA) and the celiac trunk (CT) (Figure 1). The pancreatic head was fully mobilized en-bloc with the lympho-neural tissue lying between the SMA and the CT (so called mesopancreas). No attempt was made to detach the vascular segment from the tumor, with the aim of maximize the probability to achieve an R0 resection (25,26) (Figure 2) (Video 1). In general, segmental vein resection was preferred over tangential resection. In case of segmental vein resection, depending on the length of the resected vessel, reconstruction was performed either by direct end-to-end anastomosis (type III vein resection) (Video 2) or using an interposition graft (type IV vein resection) (Video 3) (4). In case of a large side-wall resection, vein repair is performed using a large peritoneal patch or using an autologous vein patch (Video 1) (14). When resection involved the spleno-mesenteric junction, splenic vein drainage was always restored. The splenic vein was either reimplanted on the reconstructed porto-mesenteric vein or on the inferior vena (Figure 3A,B).

Figure 1 Anterior supramesocolic artery-first approach to the superior mesenteric artery (SMA). The SMA is dissected in a cephalad direction until the aortic plane. Following elevation of the splenic vein, dissection is carried out also along the right side of the celiac trunk until the specimen is fully mobilized en-bloc with the involved segment of the vein.
Figure 2 Operative field after completion of retroperitoneal dissections. Note that the right side of both superior mesenteric artery (SMA) and celiac trunk are skeletonized, that the inferior vena cava, the left renal, and the right diaphragmatic crus are all in clear view. The yellow dashed line shows the area covered by the right celiac ganglion, that was removed en-bloc with the specimen. The purple triangle, shows the area formerly filled by the extrapancreatic nerve plexus (also identified as to “mesopancreas”).
Figure 3 Spleno-caval shunt. (A) In preparation for the vascular anastomosis the splenic vein is properly oriented by a stay suture placed at the lower corner of the anastomosis. The suture starts at the opposite corner using a short (10 cm) suture of 6/0 e-PTFE. (B) Anastomosis completed. E-PTFE, expanded polytetrafluoroethylene.

Vascular sutures were performed using fine sutures (6/0 or 7/0) of expanded polytetrafluoroethylene (Gore, W. L. Gore & Associates, USA).

Histopathological assessment

Pathology analysis of resected specimens was conducted according to the Leeds protocol (15,27). Briefly, circumferential margins were identified and stained using different colors in the fresh specimen. After fixation in 10% buffered formalin the specimen was sliced in <5-mm-thick axial slices. Each slice was examined in a single large slide. Seven margins were assessed: anterior surface, posterior surface, vein bed, SMA groove, pancreatic neck, proximal duodenum/stomach, and common bile duct. Margins were defined positive (R1) if cancer cells were identified ≤1 mm of any margin.

Statistical analysis

Fisher’s exact test and Pearson Chi square test were used to compare categorical variables between groups as appropriate. The relation between the independent variable “length of the resected vein” and the dependent variable “need for jump graft” was evaluated with a logistic regression. The cut off-value of the independent variable was calculated with receiver operating characteristic (ROC) curves.

ROC curves were used to calculate the cut-off value for using a vascular graft for vein reconstruction.

OS and DFS were calculated by using Kaplan-Meier curves.

Statistical analysis was carried out using JMP® 9.0.1 software package for Mac, Copyright© SAS Institute Inc., SAS campus Drive, Cary, NC, USA.


During the study period a total of 184 RAPDs were performed. RAPD-VR was performed in 26 patients (14.1%). As shown in Figure 4, the number of RAPD-VR significantly increased during the last 4 years (P=0.01; Chi square). The results of 22 patients (84.6%) who received an isolated vein resection are presented herein. The remaining 4 patients received either an isolated arterial resection (n=3; 11.5%) or a combined arterial and venous resection (n=1; 3.8%).

Figure 4 Number of RAPD-VR performed each year from 2011 to 2019. RAPD-VR, robot-assisted pancreaticoduodenectomy with vascular resection.

The baseline characteristics of the study population are summarized in the Table 1. Vein involvement was suspected based on imaging findings in 14 patients (63.6%). In these patients RAPD-VR was planned before surgery. In the remaining 8 patients tumor adherence to the porto-mesenteric vein was discovered during the procedure. The decision to proceed with robotic resection, instead of converting the patients to an open approach, was based on the limited extension of vascular involvement (that was instead missed at preoperative studies) and the judgement that resection could have been performed safely even when associating a vascular procedure.

Table 1
Table 1 Baseline preoperative characteristics of the population
Full table

The main operative and post-operative results are summarized in Table 2. There was one conversion to open surgery (1/22; 4.5%). This conversion occurred at the end of the procedure because of diffuse bleeding in a patient with previous bone marrow transplant and multiple comorbidities. The pylorus was spared in nearly all patients (19/22: 86.4%), as per our institutional policy (28). The mean vascular clamping time was 33.75±9.2 minutes and the mean vascular anastomotic time was 20.5±2.6 minutes. Despite long operative times (610.0±83.5 minutes) only 2 patients (9.1%) required intraoperative blood transfusions. The superior mesenteric vein was resected in 9 patients (40.9%), the portal vein in 3 patients (13.6%) and the porto-mesenteric junction in 10 patients (45.5%). There were 1 type I (4.5%), 3 type II (13.6%), 10 type III (45.5%) and 8 type IV (36.4%) resections. In type II resection the side-wall defect was closed using a peritoneal patch graft in two patients (29) and a patch of right gonadal vein in one patient. In type IV resections the left internal jugular vein was used as jump graft in 7 patients. In one patient the interposition graft was a paneled saphenous vein graft. Need to use of a jump was associated with the length of resected vein segment (P=0.04; Chi square), with a cut-off of 1.3 cm (AUC =0.78).

Table 2
Table 2 Intraoperative features and post-operative complications
Full table

The pancreatic remnant was managed by means of duct-to mucosa anastomosis in all procedures. In the first 10 consecutive patients a Cattell-Warren pancreaticojejunostomy was performed (45.5%) while in the following 12 patients a modified Blumgart pancreaticojejunostomy was adopted (54.5%). Using these techniques, one patient developed a grade B POPF (4.5%), and two patients a biochemical leak.

Two patients died after RAPD-VR. Both deaths occurred early on during this experience. In the overall series of RAPD these fatalities occurred at case 23 and 46, respectively, in the series of RAPD-VR at case 1 and 5, respectively.

Patency of vein reconstruction was documented in 19 patients (86.4%). One asymptomatic patient developed vein thrombosis that was incidentally discovered during the initial hospital stay. The patient was treated with intravenous infusion of sodium heparin and the patient had no clinical consequences.

Final pathology diagnosis was pancreatic ductal adenocarcinoma in 18 patients (81.8%). Other tumor types were adenosquamous carcinoma (n=2; 9.1%), malignant intraductal papillary mucinous neoplasm (n=1; 4.5%), and neuroendocrine cancer (n=1; 4.5%). R1 resection was documented in 11 patients (50.0%). Six had R1 at multiple margins (27.3%). Vein infiltration was confirmed in 13 specimens (59.1%). A summary of histopathology analysis of resected specimens is provided in Table 3.

Table 3
Table 3 Histopathological features
Full table

After a median follow-up period of 19.9 (5.0–33.3) months, median OS was 39.7 (27.5–not available) months. Tumor recurrence was documented in 6 patients (27.3%). Isolated local recurrence developed in 1 patient (4.5%). Mean DFS was 32.9 months (11.5–45.8).


In open surgery we have pursued PD-VR since the late 1980s (16). Overall, we have performed over 500 pancreatectomies with associated vascular procedures and we have established standardized techniques to face all operative scenarios. In essence, our efforts were finalized not just to develop methods permitting safe handling and reconstruction of large peripancreatic vessels, but also oncologically sound procedures aimed at maximizing local radicality. In right-sided resections, these techniques include an artery first approach to both SMA and CT, with en-bloc removal of the lympho-neural tissue lying in the triangle between the superior mesenteric-portal vein, the SMA, and the CT (so called mesopancreas or extrapancreatic neural plexus). No attempt is made to detach the tumor from the vein or to thin down tumor adherence so that eventually a side-wall, limited, resection could be performed. As a consequence, most of our patients receive a segmental vein resection with either type III or type IV reconstruction. We rarely perform type I resections, unless tumor adherence to the vein is extremely limited. When a side-wall resection of the vein is performed, this is typically a generous resection mandating for patch repair (type II resection).

In this study, even if with the biases connected to a monocentric retrospective analysis and the small size of the cohort, we have presented the results of 22 RAPD-VR. In keeping with the principles that we have established in open surgery, 18 of 22 RAPD-VR (81.8%) were segmental vein resections. The other four procedures were type I resection in one patient and type II resection in three patients. Therefore, robotic assistance permits to faithfully reproduce the open technique. However, our results are unique. Indeed, in the largest series of RAPD-VR reported so far 50 procedures are described including 43 type I resections (27 managed by linear stapler and 16 by venorrhaphy), 6 type II resections, and I type III resection (12). These figures show that different approaches to vein resection and reconstruction are followed at different institutions even when robotic assistance is used. Clearly type I resection adds little to standard RAPD while type IV resection adds, at least, technical complexity. Our series shows that robotic assistance permits all types of resections and reconstructions, in the setting of patients selected for a minimally invasive approach.

Our study also confirms the general feasibility of RAPD-VR, as witnessed by the low conversion rate and the low proportion of patients requiring blood transfusions. Actually, we never had to convert a patient due to difficulties in dissection and/or vein reconstruction. The only case of conversion to open surgery, occurred after completion of tumor resection and vascular reconstruction due to diffuse bleeding, in a patient with previous bone marrow transplant, that was difficult to control under minimally invasive conditions. Our conversion rate favorably compares with the other few series reported in the literature that show a conversion rate between 10% (12) and 36.4% (30). It is important to underscore that our low conversion rate was achieved in the context of low blood transfusion requirements showing that our procedures had a smooth intraoperative course. On the other hand, RAPD-VR appears to be a complex procedure, as demonstrated by long operative times and high mortality rates. Therefore, RAPD-VR should be implemented with caution in centers that have already surpassed their learning curve with the standard procedure (31,32). We also believe that background experience in PD-VR is important. A critical appraisal on mortality following RAPD-VR shows that we do not have enough data to draw final conclusions on this regard. Indeed, we have reported a mortality rate of 9%, caused by two deaths occurring in 22 procedures. Beane and coworkers reported a rate of 8% in 50 procedures (12), while Shyr and coworkers described no deaths in 11 patients (30). Other, small, series simply did not report on post-operative mortality (33). The yet limited number of procedures could overemphasize the relative impact of rare events, such as post-operative mortality making current rates still immature for critical evaluation. However, RAPD-VR has a mortality risk that should not be underestimated. Concerning the present series, we had two post-operative deaths. The clinical history of the first of these two patients begins with a bleeding episode originating from a pancreaticoduodenal artery. Hemorrhage was fixed at repeat surgery but the patient eventually died 40 days after the index operation due to widespread pneumonia with multi-resistant bacteria. The second patient suddenly bled on postoperative day fifteenth due to a “tear” close to the origin of the SMA, in the absence of signs of POPF and/or local sepsis. The breach was promptly repaired without massive blood loss but the patient developed intraoperative cardiac arrest and could not be resuscitated. We speculated that this vascular lesion was caused by unintentional thermal injury during arterial dissection. This one of the main reasons why we do not employ energy devices close to major arteries. We prefer to perform these dissections using cold scissors, and seal lymphatic channels and vessels using a combination of clips and ligatures (24). This technique can be tedious and is time consuming, but we have not observed other cases of this type of postoperative bleeding in 168 consecutive RAPDs.

We have already underscored that in RAPD-VR we tried to duplicate the technique that we have established in the open procedure. Indeed, we performed 18 segmental vein resections. In open surgery, after a Cattel-Braasch maneuver, the use of a jump graft is rarely required even when the length of the resected vein segment exceeds three centimeters. In minimally invasive approach, the fact that the Cattel-Braasch maneuver is unpractical and that the reverse Trendelenburg position further outdistance the two cut ends of the vein, a jump graft could be required more frequently. We have shown that direct reconstruction is still feasible in over half of the patients undergoing segmental vein resection (11/19; 57.9%). An interposition graft is required when the length of the resected vein segment exceeds 1.3 cm.

The rate of R0 resection is an important quality metric in pancreatic oncologic surgery. In our series we observed a rate of R1 resections of 52.2%. Is important to underscore that this result was observed after systematic study of specimens according to stringent pathology methods and in a series of patients who did not receive neoadjuvant treatments. The use of these treatments, also in the setting of RAPD, was shown to increase the rate of R0 resections (12). The oncologic adequacy of our technique is shown also by the number of retrieved lymph nodes that largely exceeds the standard defined by the American Joint Committee on Cancer for staging of pancreatic cancer (34). The fact that only one patient developed isolated local recurrence further reinforces the value of our approach.

It is also important to underscore that we have observed only one grade B POPF giving an overall rate of clinically relevant POPF of approximately 4%. This result is in keeping with previous observations (12), and is probably related to the fact that nearly all patients requiring RAPD-VR are affected by pancreatic cancer so that they have firm gland texture and enlarged main pancreatic ducts.

Prevention of vein thrombosis after PD-VR and RAPD-VR is important. Our general policy, however, does not encourage enhanced anticoagulation after vein resection and reconstruction (16). One vein thrombosis was observed in the early postoperative course, without clinical consequences. Our rate of thrombosis is in keeping with data reported in the literature (35) and suggests that there is probably no need for a specific antithrombotic protocol in these patients (36).

In conclusion, RAPD-VR is feasible, but safety remains to be established. As more data are needed to draw final conclusions on safety of RAPD-VR, we discourage groups with limited experience in PD-VR and/or that have not surpassed the learning curve in RAPD to embark upon these extra complex procedures.


Funding: None.


Provenance and Peer Review: This article was commissioned by the Guest Editor (Edoardo Rosso) for the series “Mini-invasive pancreaticoduodenectomy: are we moving from a “feasible” intervention to be considered the standard?” published in Laparoscopic Surgery. The article was sent for external peer review organized by the Guest Editor and the editorial office.

Reporting Checklist: The authors have completed the STROBE reporting checklist. Available at

Data Sharing Statement: Available at

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at The series “Mini-invasive pancreaticoduodenectomy: are we moving from a “feasible” intervention to be considered the standard?” was commissioned by the editorial office without any sponsorship or funding. UB serves as an unpaid editorial board member of Laparoscopic Surgery from Nov 2017 to Nov 2021. The other authors have no other conflict of interest and nothing to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013). The study was approved by ethics board of the University of Pisa (CEAVNO) and informed consent was taken from all the patients

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See:


  1. Raimondi S, Maisonneuve P, Lowenfels AB. Epidemiology of pancreatic cancer: an overview. Nat Rev Gastroenterol Hepatol 2009;6:699-708. [Crossref] [PubMed]
  2. Croome KP, Farnell MB, Que FG, et al. Pancreaticoduodenectomy with Major Vascular Resection: a Comparison of Laparoscopic Versus Open Approaches. J Gastrointest Surg 2015;19:189-94. [Crossref] [PubMed]
  3. Ravikumar R, Sabin C, Hilal MA, et al. Portal vein resection in borderline resectable pancreatic cancer: A United Kingdom multicenter study. J Am Coll Surg 2014;218:401-11. [Crossref] [PubMed]
  4. Bockhorn M, Uzunoglu FG, Adham M, et al. Borderline resectable pancreatic cancer: a consensus statement by the International Study Group of Pancreatic Surgery (ISGPS). Surgery 2014;155:977-88. [Crossref] [PubMed]
  5. Kaneoka Y, Yamaguchi A, Isogai M. Portal or superior mesenteric vein resection for pancreatic head adenocarcinoma: Prognostic value of the length of venous resection. Surgery 2009;145:417-25. [Crossref] [PubMed]
  6. Al-Haddad M, Martin JK, Nguyen J, et al. Vascular resection and reconstruction for pancreatic malignancy: A single center survival study. J Gastrointest Surg 2007;11:1168-74. [Crossref] [PubMed]
  7. Siriwardana HPP, Siriwardena AK. Systematic review of outcome of synchronous portal-superior mesenteric vein resection during pancreatectomy for cancer. Br J Surg 2006;93:662-73. [Crossref] [PubMed]
  8. Allema JH, Reinders ME, Van Gulik TM, et al. Portal vein resection in patients undergoing pancreatoduodenectomy for carcinoma of the pancreatic head. Br J Surg 1994;81:1642-6. [Crossref] [PubMed]
  9. Sindelar WF. Clinical Experience with Regional Pancreatectomy for Adenocarcinoma of the Pancreas. Arch Surg 1989;124:127-32. [Crossref] [PubMed]
  10. Zureikat AH, Postlewait LM, Liu Y, et al. A multi-institutional comparison of perioperative outcomes of robotic and open pancreaticoduodenectomy. Ann Surg 2016;264:640-9. [Crossref] [PubMed]
  11. King JC, Zeh HJ, Zureikat AH, et al. Safety in Numbers: Progressive Implementation of a Robotics Program in an Academic Surgical Oncology Practice. Surg Innov 2016;23:407-14. [Crossref] [PubMed]
  12. Beane JD, Zenati M, Hamad A, et al. Robotic pancreatoduodenectomy with vascular resection: Outcomes and learning curve. Surgery 2019;166:8-14. [Crossref] [PubMed]
  13. Wang X, Cai Y, Zhao W, et al. Laparoscopic pancreatoduodenectomy combined with portal-superior mesenteric vein resection and reconstruction with interposition graft: Case series. Medicine (Baltimore) 2019;98:e14204. [Crossref] [PubMed]
  14. Dokmak S, Aussilhou B, Calmels M, et al. Laparoscopic pancreaticoduodenectomy with reconstruction of the mesentericoportal vein with the parietal peritoneum and the falciform ligament. Surg Endosc 2018;32:3256-61. [Crossref] [PubMed]
  15. Kauffmann EF, Napoli N, Menonna F, et al. Robotic pancreatoduodenectomy with vascular resection. Langenbecks Arch Surg 2016;401:1111-22. [Crossref] [PubMed]
  16. Boggi U, Del Chiaro M, Croce C, et al. Prognostic implications of tumor invasion or adhesion to peripancreatic vessels in resected pancreatic cancer. Surgery 2009;146:869-81. [Crossref] [PubMed]
  17. Napoli N, Kauffmann EF, Perrone VG, et al. The learning curve in robotic distal pancreatectomy. Updates Surg 2015;67:257-64. [Crossref] [PubMed]
  18. Napoli N, Kauffmann EF, Palmeri M, et al. The Learning Curve in Robotic Pancreaticoduodenectomy. Dig Surg 2016;33:299-307. [Crossref] [PubMed]
  19. Dindo D, Demartines N, Clavien PA. Classification of surgical complications: A new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 2004;240:205-13. [Crossref] [PubMed]
  20. Bassi C, Marchegiani G, Dervenis C, et al. The 2016 update of the International Study Group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 Years After. Surgery 2017;161:584-91. [Crossref] [PubMed]
  21. Wente MN, Bassi C, Dervenis C, et al. Delayed gastric emptying (DGE) after pancreatic surgery: A suggested definition by the International Study Group of Pancreatic Surgery (ISGPS). Surgery 2007;142:761-8. [Crossref] [PubMed]
  22. Wente MN, Veit JA, Bassi C, et al. Postpancreatectomy hemorrhage (PPH)-An International Study Group of Pancreatic Surgery (ISGPS) definition. Surgery 2007;142:20-5. [Crossref] [PubMed]
  23. Slankamenac K, Graf R, Barkun J, et al. The comprehensive complication index: A novel continuous scale to measure surgical morbidity. Ann Surg 2013;258:1-7. [Crossref] [PubMed]
  24. Boggi U, Signori S, De Lio N, et al. Feasibility of robotic pancreaticoduodenectomy. Br J Surg 2013;100:917-25. [Crossref] [PubMed]
  25. Inoue Y, Saiura A, Yoshioka R, et al. Pancreatoduodenectomy with systematic mesopancreas dissection using a supracolic anterior artery-first approach. Ann Surg 2015;262:1092-101. [Crossref] [PubMed]
  26. Chowdappa R, Challa VR. Mesopancreas in Pancreatic Cancer: Where do We Stand – Review of Literature. Indian J Surg Oncol 2015;6:69-74. [Crossref] [PubMed]
  27. Verbeke CS, Leitch D, Menon K V., et al. Redefining the R1 resection in pancreatic cancer. Br J Surg 2006;93:1232-7. [Crossref] [PubMed]
  28. Mosca F, Giulianotti PC, Balestracci T, et al. Preservation of the pylorus in duodenocephalopancreatectomy in pancreatic and periampullary carcinoma. Chir Ital 1994;46:59-67. [PubMed]
  29. Dokmak S, Aussilhou B, Sauvanet A, et al. Parietal peritoneum as an autologous substitute for venous reconstruction in hepatopancreatobiliary surgery. Ann Surg 2015;262:366-71. [Crossref] [PubMed]
  30. Shyr BU, Chen SC, Shyr YM, Wang SE. Surgical, survival, and oncological outcomes after vascular resection in robotic and open pancreaticoduodenectomy. Surg Endosc 2020;34:377-83. [Crossref] [PubMed]
  31. Shi Y, Wang W, Qiu W, et al. Learning Curve From 450 Cases of Robot-Assisted Pancreaticoduocectomy in a High-Volume Pancreatic Center. Ann Surg 2019. Epub ahead of print. [Crossref] [PubMed]
  32. Zhang T, Zhao ZM, Gao YX, et al. The learning curve for a surgeon in robot-assisted laparoscopic pancreaticoduodenectomy: a retrospective study in a high-volume pancreatic center. Surg Endosc 2019;33:2927-33. [Crossref] [PubMed]
  33. Marino MV, Latteri MA, Ahmad A. Tangential venous resections during robotic-assisted pancreaticoduodenectomy: the results of a case series (with Video). J Gastrointest Surg 2020;24:1920-1. [Crossref] [PubMed]
  34. Kamarajah SK, Burns WR, Frankel TL, et al. Validation of the American Joint Commission on Cancer (AJCC) 8th Edition Staging System for Patients with Pancreatic Adenocarcinoma: A Surveillance, Epidemiology and End Results (SEER) Analysis. Ann Surg Oncol 2017;24:2023-30.
  35. Snyder RA, Prakash LR, Nogueras-Gonzalez GM, et al. Vein resection during pancreaticoduodenectomy for pancreatic adenocarcinoma: Patency rates and outcomes associated with thrombosis. J Surg Oncol 2018;117:1648-54. [Crossref] [PubMed]
  36. Ono Y, Tanaka M, Matsueda K, et al. Techniques for splenic vein reconstruction after pancreaticoduodenectomy with portal vein resection for pancreatic cancer. HPB (Oxford) 2019;21:1288-94. [Crossref] [PubMed]
doi: 10.21037/ls-20-94
Cite this article as: Kauffmann EF, Napoli N, Menonna F, Genovese V, Cacace C, Andrea CI, Daniela C, Vistoli F, Amorese G, Boggi U. Robot-assisted pancreaticoduodenectomy with vascular resection: technical details and results from a high-volume center. Laparosc Surg 2020;4:37.